How does the 2022 ‘Neanderthal’ Nobel Prize in medicine affect everyday practice?

¿Cómo afecta el

Jesus del Mazo, researcher at Margarita Salas Center for Biological Research.

“Yes we do not know our genetic pastwe hardly understand our Present and much less predict our future“. That speaks volumes Medical writing Maso’s Jesusspecialist Center for Biological Research Margarita Salas (CIB-CSIC), related to disclosures DNA: that Neanderthals acquired by him researcher Svante Pyabowhich was given Nobel Prize in Medicine. Align sanitaryknowing genetically how we evolved allows, according to the researcher, “to understand many diseases. genetic origin. If we find genes that are linked cancerit could have been quickly discovered if the Neanderthals had and analyzed it what consequences could this have? and how to deal with it, as has already happened in other studied genes.”

The health implications that this discovery can convey, according to the researcher, are extremely important, allowing to know and understand various situations that are difficult to understand without science. Neanderthal genetics“The same group led by Payabo studied a gene consisting of a progesterone receptor (PGR). It is an essential element early embryonic stages and maintaining the pregnancy process. If the Neanderthal genome and current populations are analyzed, the gene remained a 20 percent of the population currently. “Women with low levels of progesterone or the absence of this gene, which increases sensitivity to the hormone, are more likely to suffer from miscarriages, menstrual problems, etc.”

This fact became possible because, according to the researcher, “T The transfer of the progesterone gene from Neanderthals to Sapiens occurred as a result of interbreeding between the two, contributing to the fertility of females carrying the Neanderthal-derived gene. Therefore, we find the origin of a gene that is closely related to fertility, so at a therapeutic level it could be of great interest.”


“The origin of a gene linked to fertility at the therapeutic level may be key”


Another discovery reported by the CSIC researcher is related to another gene that is characteristic Denisovans, distantly related to Neanderthals and that they settled in Asia; “This particular gene activated hemoglobin production in areas with low oxygen levels. The Denisovans lived at high altitudes like Tibet. This gene allowed them high survival at high altitudes where oxygen levels are low, and it is still found in the population living in Tibet today. That Homo sapiens have the ability to produce hemoglobin more efficiently low oxygen levels. Thanks to the discovery achieved by the Nobel Prize, it will be possible to find the origin of more genes, their function and pathogenesis and possible therapeutic research.”

DNA preservation processes in archaeological remains

On the other hand, to maintain higher integrity that archaeological remains For further investigation, del Mazo cautions that “maintenance procedure systems must consider existing genetic information, and that it is very sensitive to radiation. “Depending on how this procedure is done, the DNA is affected and sometimes impossible to sequence.”


“Understanding possible future therapies depends a lot on where we come from genetically.”


Get to know him Homo Neanderthal genetic line At a practical level, it allows us to learn about genes that continue to affect large parts of the population today. “Understanding the current situation and possible future therapies depends a lot on knowing where we come from genetically,” recalls the CSIC researcher, who hopes to learn more about it in order to use it in different types of diseases, such as: cancer.

Although it may contain statements, data, or notes from health care facilities or professionals, the information contained in medical writing is edited and prepared by journalists. The reader is advised to consult a healthcare professional with any health-related questions.

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